For whole-home cooling, the choice is usually central air conditioning or one or more ductless mini-splits. The deciding factor is often whether your home already has ductwork.
Ductwork is the deciding factor
Central AC uses your existing ducts to cool the whole house from one unit — efficient and invisible if ducts already exist. If your home has no ducts, adding them for central AC is expensive and disruptive, which is where mini-splits shine: they need no ductwork, just a small line to each indoor head.
Efficiency and zoning
Mini-splits are very efficient and let you cool only the rooms in use (zoning), saving energy. Central AC conditions the whole home evenly. Many mini-splits are heat pumps, so they heat too — a bonus for homes with electric or no central heat.
Cost and looks
With existing ducts, central AC is often the cheaper, cleaner-looking choice. Without ducts, mini-splits are usually cheaper than adding ductwork, though the wall-mounted indoor heads are visible. Multi-zone mini-split systems add cost per zone.